Research

543 SYNBIOTIC DUO CAP PAPERs.

the research behind our synbiotic duo cap.

15 ingredients, 11 bacterial strains, over 450 clinical trials (and counting). Covering a multitude of hypotheses across digestion, immunity, cognition, skin and hormones.

Lactobacillus acidophilus NCFM

The world's most researched strain of acidophilus, especially trialled for IBS-related pain and bloating. However, given the extensive research behind it, trials are broad, covering immunity, digestion, cognition and skin health.

Bifidobacterium lactis BL04

This species has been shown to have a broad range of potential benefits - improved immune function, reduced inflammation, modulation of the gut-brain axis, implying its benefits in cognitive function and mental health.

Lactobacillus rhamnosus HN001

This strain has a specific focus on immunity, with its ability to enhance immune function and increase natural cellular immune responses. It has also demonstrated an ability to improve skin conditions like eczema.

ingredient.

543 studies.

year.

journal. Lactobacillus acidophilus NCFM

Gilliland SE, Speck ML. 1977. Antagonistic action of Lactobacillus acidophilus toward intestinal and foodborne pathogens in associative cultures. J Food Protect 40: 820-823

year. 1977

journal. Lactobacillus acidophilus NCFM

Goldin B, Gorbach SL. 1977. Alterations in fecal microflora enzymes related to diet, age, Lactobacillus supplements, and dimethylhydrazine. Cancer 40: 2421-2426

year. 1977

journal. Lactobacillus acidophilus NCFM

Goldin BR, Gorbach SL. 1980. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J Nat Cancer Instit 64: 263-265.

year. 1980

journal. Lactobacillus acidophilus NCFM

Payne DL, Welsh JD, Manion CV, Tsegaye A, Herd LD. 1981. Effectiveness of milk products in dietary management of lactose malabsorption. Amer J Clin Nutr 34: 2711-2715

year. 1981

journal. Lactobacillus acidophilus NCFM

Kim GS, Gilliland SE. 1983. Lactobacillus acidophilus as a dietary adjunct for milk to aid lactose digestion in humans. J Dairy Sci 66: 959-966.

year. 1983

journal. Lactobacillus acidophilus NCFM

Newcomer AD, Park HS, O'Brien PC, McGill DB. 1983. Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. Amer J Clin Nutr 38: 257-263.

year. 1983

journal. Lactobacillus acidophilus NCFM

Goldin BR, Gorbach SL. 1984. Alterations of the intestinal microflora by diet, oral antibiotics, and Lactobacillus: decreased production of free amines from aromatic nitro compounds, azo dyes, and glucuronides. J Nat Cancer Instit 73: 689-695.

year. 1984

journal. Lactobacillus acidophilus NCFM

Goldin BR, Gorbach SL. 1984. The effect of oral administration of Lactobacillus and antibiotics on intestinal bacterial activity and chemical induction of large bowel tumors. Dev Indus Microbiol 25: 139-150.

year. 1984

journal. Lactobacillus acidophilus NCFM

Savaiano DA, Abou El Anouar DAG, Smith DE, Levitt MD. 1984. Lactose malabsorption from yogurt, pasteurized yogurt, sweet acidophilus milk, and cultured milk in lactase-deficient individuals. Amer J Clin Nutr 40: 1219-1223.

year. 1984

journal. Lactobacillus acidophilus NCFM

McDonough FE, Hitchins AD, Wong NP, Wells P, Bodwell CE. 1987. Modification of sweet acidophilus milk to improve utilization by lactose-intolerant persons. Am J Clin Nutr 45: 570-574

year. 1987

journal. Lactobacillus acidophilus NCFM

Rao DR, Alabi SO, Chawan CB. 1991. Temporal changes of lactase activity in the gastrointestinal tract of rats fed yogurt and sweet acidophilus milk. Milchwissenschaft 46: 219-222.

year. 1991

journal. Lactobacillus acidophilus NCFM

Lin MY, Savaiano D, Harlander S. 1991. Influence of nonfermented dairy products containing bacterial starter cultures on lactose maldigestion in humans. J Dairy Sci 74: 87-95.

year. 1991

journal. Lactobacillus acidophilus NCFM

Nielsen JW, Gilliland SE. 1992. The lactose hydrolyzing enzyme from Lactobacillus acidophilus. Cult Dairy Prod J 27:20-28.

year. 1992

journal. Lactobacillus acidophilus NCFM

Montes RG, Bayless TM, Saavedra JM, Perman JA. 1995. Effect of milks inoculated with Lactobacillus acidophilus or a yogurt starter culture in lactose-maldigesting children. J Dairy Sci 78: 1657-1664.

year. 1995

journal. Lactobacillus acidophilus NCFM

Wagner RD, Pierson C, Warner T, Dohnalek M, Farmer J, Roberts L, Hilty M, Balish E. 1997. Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Infect Immun 65: 4165-4172.

year. 1997

journal. Lactobacillus acidophilus NCFM

Mustapha A, Jiang T, Savaiano DA. 1997. Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk: Influence of bile sensitivity, lactose transport, and acid tolerance of Lactobacillus acidophilus. J Dairy Sci 80: 1537-1545.

year. 1997

journal. Lactobacillus acidophilus NCFM

Wagner RD, Warner T, Roberts L, Farmer J, Dohnalek M, Hilty M, Balish E. 1998. Variable biotherapeutic effects of Lactobacillus acidophilus isolates on orogastric and systemic candidiasis in immunodeficient mice. Rev Iberoam Micol 15: 271-276.

year. 1998

journal. Lactobacillus acidophilus NCFM

Rao CV, Sanders ME, Indranie C, Simi B, Reddy BS. 1999. Prevention of colonic preneoplastic lesions by the probiotic Lactobacillus acidophilus NCFMTM in F344 rats. Int J Oncol 14: 939-944.

year. 1999

journal. Lactobacillus acidophilus NCFM

Tejada-Simon MV, Lee JH, Ustunol Z, Pestka JJ. 1999. Ingestion of yogurt containing Lactobacillus acidophilus and Bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. J Dairy Sci 82: 649-660.

year. 1999

journal. Lactobacillus acidophilus NCFM

Wagner RD, Dohnalek M, Hilty M, Vazquez-Torres A, Balish E. 2000. Effects of probiotic bacteria on humoral immunity to Candida albicans in immunodeficient bg/bg-nu/nu and bg/bg-nu/+ mice. Rev Iberoam Micol 17: 55-59

year. 2000

journal. Lactobacillus acidophilus NCFM

Wagner RD, Pierson C, Warner T, Dohnalek M, Hilty M, Balish E. 2000. Probiotic effects of feeding heat-killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-colonized immunodeficient mice. J Food Prot 63: 638-644.

year. 2000

journal. Lactobacillus rhamnosus HN001

Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. 2000. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr. 83: 167-176.

year. 2000

journal. Lactobacillus rhamnosus HN001

Tannock GW, Munro K, Harmsen HJM, Welling GW, Smart J, Gopal PK. 2000. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl Environ Microbiol. 66: 2578-2588

year. 2000

journal. Lactobacillus rhamnosus GG

Probiotics and gastrointestinal health.

year. 2000

journal. Lactobacillus rhamnosus HN001

Gill HS, Rutherfurd KJ. 2001. Immune enhancement conferred by oral delivery of Lactobacillus rhamnosus HN001 in different milk-based substrates. J Dairy Res. 68: 611-616.

year. 2001

journal. Lactobacillus rhamnosus HN001

Gill HS, Rutherfurd KJ. 2001. Viability and dose-response studies on the effects of the immunoenhancing lactic acid bacterium Lactobacillus rhamnosus in mice. Br J Nutr. 86: 285-289

year. 2001

journal. Lactobacillus rhamnosus HN001

Gill HS, Shu Q, Lin H, Rutherfurd KJ, Cross ML. 2001. Protection against translocating Salmonella typhimurium infection in mice by feeding the immuno-enhancing probiotic Lactobacillus rhamnosus strain HN001. Medical Microbiology and Immunology. 190: 97-104

year. 2001

journal. Lactobacillus rhamnosus HN001

Walter J, Hertel C, Tannock GW, Lis CM, Munro K, Hammes WP. 2001. Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis. Appl Environ Microbiol. 67: 2578-2585.

year. 2001

journal. Lactobacillus rhamnosus HN001

Gill HS, Cross ML, Rutherfurd KJ, Gopal PK. 2001. Dietary probiotic supplementation to enhance cellular immunity in the elderly. Br J Biomed Sci. 58:94-96.

year. 2001

journal. Lactobacillus rhamnosus HN001

Gill HS, Rutherfurd KJ. 2001. Probiotic supplementation to enhance natural immunity in the elderly: effects of a newly characterized immunostimulatory strain Lactobacillus rhamnosus HN001 (DR20TM) on leucocyte phagocytosis. Nutr Res. 21: 183-189.

year. 2001

journal. Lactobacillus rhamnosus HN001

Gill HS, Rutherfurd KJ, Cross ML. 2001. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J of Clin Immunol. 21: 264-271.

year. 2001

journal. Lactobacillus rhamnosus HN001

Sheih YH, Chiang BL, Wang LH, Liao C, Gill HS. 2001. Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J Am Coll Nutr. 20: 149-156

year. 2001

journal. Lactobacillus acidophilus NCFM

Kim EA, Baick SC, Chung WH. 2002. A study on growth inhibition of Escherichia coli and Salmonella typhimurium by lactic acid bacteria. J Animal Sci Technol 44: 491-498.

year. 2002

journal. Lactobacillus acidophilus NCFM

Sui J, Leighton S, Busta F, Brady L. 2002. 16S ribosomal DNA analysis of the faecal lactobacilli composition of human subjects consuming a probiotic strain Lactobacillus acidophilus NCFM. J Appl Microbiol 93: 907-912.

year. 2002

journal. Lactobacillus acidophilus NCFM

Varcoe J, Zook C, Sui J, Leighton S, Busta F, Brady L. 2002. Variable response to exogenous Lactobacillus acidophilus NCFM consumed in different delivery vehicles. J Appl Microbiol 93: 900-906.

year. 2002

journal. Lactobacillus rhamnosus HN001

Cross ML, Mortensen RR, Kudsk J, Gill HS. 2002. Dietary intake of Lactobacillus rhamnosus HN001 enhances production of both TH1 and Th2 cytokines in antigen-primed mice. Med Microbiol Immunol. 191: 49-53.

year. 2002

journal. Lactobacillus rhamnosus HN001

Shu Q, Gill HS. 2002. Immune protection mediated by the probiotic Lactobacillus rhamnosus HN001 (DR20) against Escherichia coli O157:H7 infection in mice. FEMS Immunol Med Microbiol. 34: 59-64.

year. 2002

journal. Lactobacillus acidophilus NCFM

Varcoe JJ, Krejcarek G, Busta F, Brady L. 2003. Prophylactic feeding of Lactobacillus acidophilus NCFM to mice attenuates overt colonic hyperplasia. J Food Prot 66: 457-65.

year. 2003

journal. Lactobacillus acidophilus NCFM

Faber SM. 2003. Are probiotics useful in irritable bowel syndrome? J Clin Gastroenterol 37: 93-94.

year. 2003

journal. Bifidobacterium lactis BL04

Lammers KM, Brigidi P, Vitali B, Gionchetti P, Rizzello F, Caramelli E, Matteuzzi D, Campieri M. 2003. Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells. FEMS Immunol Med Microbiol. 8: 165-72.

year. 2003

journal. Lactobacillus acidophilus LA14

year. 2003

journal. Lactobacillus rhamnosus GG

Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG in healthy volunteers

year. 2003

journal. Lactobacillus rhamnosus GG

Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial

year. 2003

journal. Lactobacillus acidophilus NCFM

Glass MD, Courtney PD, LeJeune JT, Ward LA. 2004. Effects of Lactobacillus acidophilus and Lactobacillus reuteri cell-free supernatants on Cryptosporidium viability and infectivity in vitro. Food Microbiol 21: 423-429.

year. 2004

journal. Bifidobacterium longum BL03

Del Piano M. et al. The use of probiotics in the treatment of constipation in the elderly. CIBUS, 2005; 1(1):23-30.

year. 2005

journal. Bifidobacterium lactis BL04

Paineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. 2008. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 53: 107-13

year. 2008

journal. Lactobacillus acidophilus LA14

year. 2008

journal. Bifidobacterium breve BR03

Nicola S. et al. Interaction between probiotics and human immune cells: the prospective anti-inflammatory activity of Bifidobacterium breve BR03. AgroFOOD, 2010; 21(2):S44-47.

year. 2010

journal. Bifidobacterium bifidum BB-06

Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial

year. 2010